Results: The mean age of subjects was 9.8 years (range 2–19). Meta-analysis was conducted using a weighted z-score approach. The effects of SNPs were modeled assuming additive, recessive, and dominant effects of the minor allele.
Strata emr Pc#
The association between each single nucleotide polymorphism (SNP) and BMI was tested using linear regression adjusting for age, gender, and PC by cohort. After removing missing data and outliers based on principal components (PC) analyses, 2860 samples were used for the GWAS study.
A Genome-wide association study (GWAS) was performed with BMI z-score. To account for age and sex differences in BMI, BMI z-scores were generated using 2000 Centers of Disease Control and Prevention (CDC) growth charts. For all available samples, gender, age, height, and weight were collected and BMI was calculated. Method: Data on 5049 samples of European ancestry were obtained from the Electronic Medical Records (EMRs) of two large academic centers in five different genotyped cohorts. In order to confirm this effect in pediatric population five European ancestry cohorts from pediatric eMERGE-II network (CCHMC-BCH) were evaluated. 9Department of Veteran Affairs Medical Center, Cincinnati, OH, USAĬommon variations at the loci harboring the fat mass and obesity gene (FTO), MC4R, and TMEM18 are consistently reported as being associated with obesity and body mass index (BMI) especially in adult population.8Center for Biomedical Informatics, Harvard Medical School and Children’s Hospital Informatics Program, Boston, MA, USA.7National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.6Division of Genetics and Genomics, Department of Pediatrics, The Manton Center for Orphan Disease Research, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.5Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, USA.4Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.3School of Medicine, University of Cincinnati, Cincinnati, OH, USA.2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.1Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA.Crimmins 2,3, Lisa Martin 2,3, Imre Solti 3,4, Isaac S. Bahram Namjou 1*, Mehdi Keddache 2,3, Keith Marsolo 3,4, Michael Wagner 3,4, Todd Lingren 3,4, Beth Cobb 1, Cassandra Perry 5, Stephanie Kennebeck 2,3, Ingrid A.
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